Radioactive chitosan complex and its macroaggregates for use in internal radiation therapy and their preparation method

摘要

Radioactive chitosan complex and its macroaggregate and method for preparing thereof is capable of substituting conventional surgical operation and medicinal treatment method for hepatocellular carcinoma or metastasized liver cancer. Chitosan complex and its macroaggregate, a natural high molecular substance having a non-toxicity, bio-compatability and biodegradability are labelled with radionuclide (¹⁵⁹Sm, ¹⁶⁵Dy, ¹⁶⁶Ho, ¹⁶⁹Er) of emitting high energy beta-rays. The radioactive chitosan macroaggregate prepared as above is intrapercutaneously or intraartery injected to lesion of liver, so that it can be selectively more accumulated to a cancer cell than a normal tissue, and can treat by selectively killing the cancer cell by beta-rays emitted from the said radioactive nuclides. An ovarium cancer, a stomach cancer, a peritoneol cavity cancer, and a rheumatoid arthritis which are all known as incurable diseases can also be treated by selectively killing its lesion by means of this internal radiation therapy.