Sesquiterpenes, their preparation and their use as inhibitors acting on gamma-aminobutyric acid-benzodiazepine receptors (Sesquiterpenes, their preparations and their use as inhibitors acting on the GABA-benzodiazepine receptor)

摘要

The sesquiterpenes and pharmaceutically or veterinarily acceptable salts thereof of the following general formula (I) obtainable from the strain Acremonium atrictum XO6 / 15/458 can be obtained from the GABA-benzodiazepine C1 ^- ion transport receptor Is a binding inhibitor of betodiazepine to complexes.;In this formula, And Are each a single bond, or one is a single bond and the other is a double bond; A, , And RTI ID = 0.0 A / RTI ; / RTI Y is a double bond, or when A is a ring (a) as defined above, Y is a double bond, or an epoxy bond .;These compounds can be prepared by (i) fermenting a strain X06 / 15/458 (IMI 354451) or its mutant producing sesquiterpene in a source of carbon, nitrogen and inorganic salts, (ii) isolating sesquiterpene from the fermentation medium (Iii) optionally, converting the sesquiterpene into a pharmaceutically or veterinarily acceptable salt thereof.