Sesquiterpenes, their preparation and their use as inhibitors acting on the gaba-benzodiazepine receptor

摘要

PCT No. PCT/GB93/02632 Sec. 371 Date Aug. 29, 1995 Sec. 102(e) Date Aug. 29, 1995 PCT Filed Dec. 22, 1993 PCT Pub. No. WO94/14814 PCT Pub. Date Jul. 7, 1994Sesquiterpenes obtainable from the fungal strain Acremonium strictum XO6/15/458, and phannaceutically and veterinarily acceptable salts thereof, are inhibitors of the binding of benzodiazepine to the GABA-benzodiazepine-Cl ionophore receptor complex. These compounds are prepared by (i) fermenting, in a source of carbon, nitrogen and inorganic salts, fungal strain XO6/15/458 (IMI 354451) or a mutant thereof which produces the sesquiterpenes, (ii) isolating the sesquiterpenes from the fermentation medium; and (iii) if desired, converting the sesquiterpene into a pharmaceutically or veterinarily acceptable salt.