Modified oligonucleotide (OLIGONUCLEOTIDES MODIFIED TO IMPROVED STABILITY AT ACIC pH) to improve stability at acidic pH.

摘要

The present invention relates to acid-resistant oligonucleotides modified by alkylation at the 2 '-O-position, suitable for oral administration. The present invention also provides an orally acceptable formulation made with the modified oligonucleotide described herein as an active ingredient.