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Oligonucleotides modified to improve stability at acid pH
Oligonucleotides modified to improve stability at acid pH
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机译:寡核苷酸经过修饰可提高在酸性pH下的稳定性
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摘要
Acid resistant oligonucleotides modified by alkylation at the 2'-O-position are suitable for oral administration. Orally acceptable formulations prepared with the disclosed modified oligonucleotides as active ingredients are also provided.
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