1,2,4 triazolo 4,3-a quinoxaline compound. (1, 2, 4) triazolo 4,3-a quinoxaline compounds, their preparation and use,

摘要

The [1,2,4] triazolo [4,3-a] quinoxaline derivatives of the general formula (I) and pharmaceutically acceptable salts thereof have affinity for the AMPA receptor and are useful for the treatment of CNS symptoms, Is an antagonist associated with the type of AMPA receptor that makes it particularly useful in the treatment of a number of specific precursors caused by the hyperactivity of excitatory amino acids.;; Wherein one of R ¹ and R ² is a substituted or unsubstituted 5- or 6-membered nitrogen-containing heterocyclic ring or a substituted or unsubstituted 5- or 6-membered nitrogen-containing heterocyclic ring A fused ring system comprising; R ¹ and R ² of one another are hydrogen, alkyl, alkoxy, halogen, NO _2, NH _2, CN, CF _3, COC _1-6 - alkyl, or SO ₂ NR'R "(wherein, R 'and R" are Independently is hydrogen or alkyl; X is O or S;