Combination of Progesterone Antagonists and Anti-Estrogens with Partial Agonistic Action for Use in Hormone-Replacement Therapy for Peri -and Post-Menopausal Women)

摘要

The present invention relates to the use of at least one compound having progesterone antagonism and at least one compound having antiestrogenic activity with partial estrogen action for the manufacture of a medicament for use in hormone replacement therapy in postmenopausal and postmenopausal women. will be.;When combined with progesterone antagonists and antiestrogens, stimulation of the endometrium by progesterone antagonists caused by its partial agonist action upon use of antiestrogens alone is suppressed.;For example, the medicament according to the present invention contains onapristone (progesterone antagonist) and tamoxifen (antiestrogen).