. Method involves the following reactions: compound of the formula (II) where Z - halide is subjected for methylation and methylation product obtained of the formula (III) where Z has a value indicated above is subjected for reduction followed by acid hydrolysis of compound of the formula (IV) or acid hydrolysis followed by reduction of compound of the formula (V) where Z - as indicated above; or compound of the formula (VI) is methylated and methylation product obtained of the formula (IV) is subjected for acid hydrolysis if necessary after preliminary isolation of product of the formula (IV), or compound of the formula (IV) is subjected for hydrolysis with hydrogen bromide. Other object of invention are derivatives of trifluoromethylpivalanilide of the general formula (VII) where Y means hydrogen or halide which are intermediate products for synthesis of 2-methyl-3-trifluoromethylaniline. These derivatives were synthesized by methylation of compound of the formula (VIII) where Y - as indicated above. EFFECT: improved method of synthesis."/>
METHOD OF SYNTHESIS OF 2-METHYL-3-TRIFLUOROMETHYLANILINE, DERIVATIVES OF TRIFLUOROMETHYLPIVALANILIDE AND A METHOD OF THEIR SYNTHESIS
首页>
外国专利>
METHOD OF SYNTHESIS OF 2-METHYL-3-TRIFLUOROMETHYLANILINE, DERIVATIVES OF TRIFLUOROMETHYLPIVALANILIDE AND A METHOD OF THEIR SYNTHESIS
METHOD OF SYNTHESIS OF 2-METHYL-3-TRIFLUOROMETHYLANILINE, DERIVATIVES OF TRIFLUOROMETHYLPIVALANILIDE AND A METHOD OF THEIR SYNTHESIS
展开▼
机译：2-甲基-3-三氟甲基苯胺的合成方法，三氟甲基苯甲酰苯胺的衍生物及其合成方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
FIELD: organic chemistry. SUBSTANCE: product: 2-methyl-3-trifluoromethylaniline of the formula (I) . Method involves the following reactions: compound of the formula (II) where Z - halide is subjected for methylation and methylation product obtained of the formula (III) where Z has a value indicated above is subjected for reduction followed by acid hydrolysis of compound of the formula (IV) or acid hydrolysis followed by reduction of compound of the formula (V) where Z - as indicated above; or compound of the formula (VI) is methylated and methylation product obtained of the formula (IV) is subjected for acid hydrolysis if necessary after preliminary isolation of product of the formula (IV), or compound of the formula (IV) is subjected for hydrolysis with hydrogen bromide. Other object of invention are derivatives of trifluoromethylpivalanilide of the general formula (VII) where Y means hydrogen or halide which are intermediate products for synthesis of 2-methyl-3-trifluoromethylaniline. These derivatives were synthesized by methylation of compound of the formula (VIII) where Y - as indicated above. EFFECT: improved method of synthesis.
展开▼
机译：领域：有机化学。物质：产品：式（I）的2-甲基-3-三氟甲基苯胺<图像文件=“ 00000001.GIF” he =“ 20” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 22” />。该方法涉及以下反应：式（II）的化合物其中Z-卤化物式（III）的甲基化和甲基化产物的合成<图像文件=“ 00000003.GIF” he =“ 20” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 41” />其中Z具有上面指示的值将其还原，然后酸水解式（IV）的化合物或酸水解然后还原式（V）的化合物其中Z-如上所述;或式（VI）的化合物被甲基化并得到式（IV的甲基化产物）<图像文件=“ 00000007.GIF” he =“ 20” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 41” />如有必要，可在式（IV）的产物初步分离后进行酸水解或式（IV）的化合物进行溴化氢水解。发明的另一个目的是通式（VII）的三氟甲基新戊酰苯胺的衍生物。<图像文件=“ 00000009.GIF” he =“ 20” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 41” />其中Y表示氢或卤化物是合成2-甲基-3-三氟甲基苯胺的中间产物。这些衍生物通过式（VIII）的化合物的甲基化合成。<图像文件=“ 00000010.GIF” he =“ 20” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 41” />其中Y-如所示以上。效果：改进的合成方法。
展开▼
