PHARMACEUTICAL COMPOSITIONS, TREATMENT METHODS, DIAGNOSIS METHOD, IDENTIFICATION METHODS, RECEPTORS, CELLS, NUCLEIC ACIDS, COMPOUNDS, ANTIBODIES, AGENT OF RECEPTOR BINDING, METHOD OF RECEPTOR EXPRESSION MODULATION, METHOD OF CELL KILLING

摘要

FIELD: pharmacy, medicine, molecular biology, biotechnology. SUBSTANCE: invention is related to method and composition useful for patients suffering with different disturbances and showing anomal levels of one or more components activity of which is regulated or acts on activity of one or more receptors of inorganic ions. Also, compounds useful in these methods and compositions were given. Method involves the administration to patient therapeutically effective amount of molecule showing activity with regard to one or more receptors of inorganic ions as agent or antagonist. Preferably, molecule must act as selective against or antagonist on the Ca²⁺-receptor of one or more (but not all) cells taken in group. Group consists of parathyroid cells, osseous osteoclasts, periglomerular renal cells, proximal tubular renal cells, peripheral tubular renal cells, thick ascending branch of Henle loop cells and/or ducts collecting, keratinocyte in epidermis, parafollicular cell in thyroid (C-cells), intestinal cells, trophoblast in placenta, platelet, smooth muscle vessel cells, atrium cells, cells producing gastrin and glucagon, renal mesangial cell and mammary cells. EFFECT: increased effectiveness of combinations proposed.