NOVEL COMPOSITIONS BASED ON A SYNERGETIC MIXTURE BETWEEN AT LEAST ONE LIGAND SPECIFIC FOR RXRS AND AT LEAST ONE LIGAND SPECIFIC FOR RAR-X OR VDR, AND USES THEREOF

摘要

The invention relates to the use of new combinations based on at least a first ligand having a selective activity for the RXRs receptors and at least a second ligand having a selective activity either for the RAR-alpha receptor or for the receptor VDR, as active principles in, or for the manufacture of, pharmaceutical and / or dermatological compositions more particularly intended for modulating the proliferation and / or differentiation of a cellular system of HL-60 type, with the aim in particular of treating, by systemic route, acute promyelocytic leukemia.