Intrinsic factor - horse radish peroxidase conjugates and a method for increasing the stability thereof

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  机译： 内在因子-马萝卜过氧化物酶结合物及其增加稳定性的方法

• 4. Intrinsic Factor - Horse Radish Peroxidase Conjugates and a Method for Increasing the Stability Thereof [P] . CA2104412A1 . 1994-03-05

  机译： 内在因素-辣根过氧化物酶缀合及其增加稳定性的方法

• 5. Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof [P] . 美国专利： US5350674A . 1994-09-27

  机译： 内在因子-马过氧化物酶缀合物及其增加稳定性的方法

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• 1. A Green Approach towards the Synthesis of Enantio Pure Diols Using Horse Radish Peroxidase Enzyme Immobilized on Magnetic Nanoparticles [J] . Seelam Siva Deepthi ,Ernala Prasad ,Basireddy Venkata Subba Reddy . 绿色与可持续化学（英文） . 2014,第1期
• 2. Modification of Periodate Oxidation Method to Produce HRP-IgG Conjugate and Test its Stability Overtime [J] . Nataliia Pavliuchenko ,Victoria Hazarnian ,Marcel Bassil . 美国分子生物学期刊（英文） . 2019,第2期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. A Novel Radish Phospholipid Hydroperoxide Glutathione Peroxidase Is Located in Mitochondria [J] . YANGXiao-Dong LIUJin-Yuan . 遗传学报：英文版 . 2004,第9期
• 5. 利用主成分分析计算方法定量描述卷烟内在质量稳定性的初步探索 [C] . 石怀彬 ,甘学文 ,陈晶波 . 中国烟草学会第五届理事会第三次会议暨学术年会 . 2007
• 6. 中国制造业国际竞争力及影响因素再考察——增加值贸易和传统贸易统计方法比较视角 [A] . 李春 . 2016