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Method of diagnosing ovarian, endometrial, and colon cancers with monoclonal antibodies OXA and OXB

机译:用单克隆抗体OXA和OXB诊断卵巢癌,子宫内膜癌和结肠癌的方法

摘要

A method for detecting the presence of cancer employs monoclonal antibody OXA or OXB, antibodies which bind to the antigen bound by monoclonal antibody OXA or OXB, or fragments of the foregoing which bind to the antigen bound by monoclonal antibody OXA or OXB. The method comprises contacting a sample of a biological fluid from a subject with the antibody under conditions permitting the antibody to form a reaction product, and then detecting the presence or absence of the reaction product. The method is particularly useful for monitoring the progression of treatment in a patient previously diagnosed as having ovarian or colon cancer. The method is also useful for detecting and monitoring endometrial cancer, and for detecting colon cancer.
机译:用于检测癌症的存在的方法使用单克隆抗体OXA或OXB,与单克隆抗体OXA或OXB结合的抗原结合的抗体,或与单克隆抗体OXA或OXB结合的抗原结合的前述片段。该方法包括在允许抗体形成反应产物的条件下使来自受试者的生物流体样品与抗体接触,然后检测反应产物的存在或不存在。该方法对于监测先前被诊断患有卵巢癌或结肠癌的患者的治疗进展特别有用。该方法还可用于检测和监测子宫内膜癌,以及用于检测结肠癌。

著录项

  • 公开/公告号US5486456A

    专利类型

  • 公开/公告日1996-01-23

    原文格式PDF

  • 申请/专利权人 DUKE UNIVERSITY;

    申请/专利号US19940216616

  • 发明设计人 FENG J. XU;YIN H. YU;ROBERT C. BAST JR.;

    申请日1994-03-23

  • 分类号G01N33/574;G01N33/53;C07K16/30;

  • 国家 US

  • 入库时间 2022-08-22 03:39:09

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