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Solid phase oligonucleotide synthesis using phospholane intermediates
Solid phase oligonucleotide synthesis using phospholane intermediates
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机译:使用磷烷中间体的固相寡核苷酸合成
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摘要
Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer- O- [1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1, 3,2- dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.
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