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The cross-linked polyethylene oxide coat which improves the biological compatibility of the transplantation possible medical device
The cross-linked polyethylene oxide coat which improves the biological compatibility of the transplantation possible medical device
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机译:改善了可移植医疗器械生物相容性的交联聚环氧乙烷涂层
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摘要
Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized, end-capped PEO which is attached at one end to the medical device. The PEO compounds are then cross-linked by 1) exposure to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network or 2) by reacting the free functionalized ends of a sufficient number of bound PEO compounds with a crosslinking agent whose functional groups are reactive toward the bound PEO chain's functionalized ends. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
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