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NEW DNA POLYMERASE HAVING PROOFREADING 3',5'-EXONUCLEASE ACTIVITY
NEW DNA POLYMERASE HAVING PROOFREADING 3',5'-EXONUCLEASE ACTIVITY
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机译:新的DNA聚合酶具有校对的3',5'-核酸外切酶活性
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摘要
The invention relates to DNA polymerases which are capable of proofreading 3'-5' exonuclease activity during DNA sequencing of a DNA strand, such that the DNA polymerase functions to excise mismatched nucleotides from the 3' terminus of the DNA strand at a faster rate than the rate at which the DNA polymerase functions to remove nucleotides matched correctly with the nucleotides of the template, and which DNA polymerase does not exhibit 5'-3' exonuclease activity. The invention also relates to isolated and cloned DNA sequences derived from the Bacillus stearothermophilus thermostable DNA polymerase, as well as the expressed polymerase itself.
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