Peptide sequence forming mucin type sugar chain and modification technology to mucin type sugar binding protein

摘要

An amino acid sequence in which a mucin type sugar chain is specifically introduced into a protein or peptide chain, and an introduction of a mucin type sugar chain introduction technique to a protein or peptide using the arrangement are disclosed. In the presence of UDP GalNAc: polypeptide. Alpha. 1, O-GalNAc transferase, the protein or peptide containing the sequence represented by the following formula (I) is derived from the UDP GalNAc (where UDP is uyridine 5 u2032 diphosphate, GalNAc is N-acetylgalactosamine), and GalNAc is used as a peptide Is introduced into x (0) amino acids.(where x (- 1) and X (2) independently represent any amino acid, X (0) represents t or s, and X (1) and X (3) independently represent any amino acid, but at least one represents P. )