NEW ADMINISTRATION EMBODIMENT OF HYDROXOCOBALAMINE AND ITS USE FOR PRUSSIC ACID INTOXICATION

摘要

PROBLEM TO BE SOLVED: To obtain a composition containing the subject compound, useful for treating cyanide poisoning, excellent in stability and preservable for a long period. SOLUTION: Hydroxocobalamin is first lyophilized in an acidic medium; thereafter, the lyophilized product is dissolved again in a neutral saline solution (pref. an aqueous solution of sodium chloride, esp. physiological saline solution). To obtain the lyophilized product, a hydroxocobalamin solution is prepared in an acidic medium which may be incorporated with a filler (pref. at pH3.5-5.5) and then lyophilized in a vessel intended to use.