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Optical active amino bear run derivative
Optical active amino bear run derivative
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机译:光学活性氨基熊游衍生物
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摘要
PURPOSE: To obtain a crystalline salt of an optically active aminocoumarane derivative having high water-solubility and stability and useful as an agent for suppressing the formation of lipid peroxide, especially an agent for improving, treating and preventing the cerebral function disorder caused by cerebral apoplexy and head injury. ;CONSTITUTION: A crystalline salt of an optically active isomer of 5-amino-2,4,6,7- tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan expressed by formula I, i.e., the (S)-(+) isomer of formula II and (R)-(-) isomer of formula III. The salt is preferably dihydrochloride or fumarate. The crystalline salt can be produced by reacting a compound of formula I with an optically active organic acid or by reacting an optically active compound of formula II or formula III with an acid.;COPYRIGHT: (C)1994,JPO&Japio
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