Method prepares the glycine that N-substituted glycine ester or N- replace, and prepares Indophenols and prepares indigo derivative method

摘要

The general formula I of the glycine a process for preparing N-substituted glycine ester or N- substitutions is also described in the present invention, wherein the manufacture craft is the general formula II of glyoxalic acid hemiacetal ester, wherein R is as shown below and RI3 indicates that alkyl has being brought into and amine reaction formula III for 1 to 4 carbon atom, wherein Ri1 is as the diluent of the 1:1 in molar ratio to 1.5 indicated below, such as ethyl alcohol, the diluent that 0 degC reflux temperatures use and pressure are up to from 0.1 until 2 MPa in temperature. Resulting intermediate, then,In the presence of a hydrogenation catalyst processing containing be used as active constituent, preferably under the reaction condition of nickel and diluent with hydrogen pressure be from 4 to 8 MPa, wherein N-substituted glycine ester formula obtain. The N-substituted glycine ester can optionally be separated with reaction mixture and optionally salt is converted into free acid. Also description production indoxyl and indigo derivative, wherein R indicates that alkyl that hydrogen or group contain 1 to 4 carbon atom and Ri1 represent the substituted phenyl containing 1 to 4 carbon atom or optionally have alkoxy carbonyl phenyl or naphthyl with hydroxyl or phenyl substitution.