tritium labelled fibrinogen receptor antagonists, their use and process for their manufacture

摘要

The present invention relates to novel fibrinogen receptor antagonists labelled with a detectable atom, which have a comparable or higher affinity for the receptor than 125I-fibrinogen and whose binding is not impaired by foreign proteins, in particular the tritium-labelled fibrinogen receptor antagonists according to Claim 3 which, in the presence of foreign protein, e.g. of albumin or of fibrinogen, have an affinity (KD) of less than 500 nM for the receptor, their use as ligands in the fibrinogen receptor binding test or for determination of the concentration of fibrinogen receptor antagonists, and to processes for their production.