Trans (+/-) - 6 - (3- or 4-carboxamido-substituted pyrrol-1-yl) -alkyl -4-hydroxypyran-2-ones and hydroxy acids derived from their preparation and pharmaceutical preparations containing these compounds and their use of these compounds for the preparation of pharmaceutical preparations

摘要

Certain trans-6-[2-(3- or 4-carboxamido-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.