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A process for the manufacture of multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
A process for the manufacture of multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
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机译:一种在盐酸盐存在下具有包封生物活性物质的多囊脂质体的制备方法
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摘要
Disclosed are large multivesicular liposomes containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and having substantially higher encapsulation efficiency and substantially slower leakage rate of the biologically active substance than in the previous art. The process comprises dissolving a lipid component in volatile organic solvents, adding an immiscible aqueous component containing a hydrochloride and one or more biologically active substances to be encapsulated, making a water-in-oil emulsion from the two components, immersing the emulsion into a second aqueous component, dividing the emulsion into small solvent spherules which contain even smaller aqueous chambers, and then evaporating the solvents to give an aqueous suspension of multivesicular liposomes encapsulating biologically active substances.
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