5,6 Dihydro pyrazole 9h (3,4-c) - 1,2,4-triazole (4 - 3 - triciclicas) pyridines

摘要

This Invention relates to 5,6 dihydro - 9H - pyrazole [3,4-c] - 1,2,4 - triazole [43 - tricyclic] pyridines which are Selective inhibitors of phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF) and as such are useful in the treatment of asthma.Arthritis, bronchitis, chronic obstructive Airway disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, as well as AIDS, sepsis,Su00e9tico shock and other diseases, such as cachexia, involving the production of TNF. The compounds of the present Invention may be combined PDE IV inhibiting activity and TNF.This Invention relates to a method of using such compounds in the treatment of anetriores diseases in Mammals.Human especialmenrte and Pharmaceutical compositions useful for the same.