New sulfa Drugs case ran 4019 / 133

摘要

Compounds of formula (i) wherein R is phenyl or substituted phenyl heterocyclyl; R is phenyl or substituted phenyl; R is Hydrogen, Lower alkyl, cyano, carboxy,Esterified carboxy phenyl, substituted phenyl, heterocyclyl or residue - conr R or ID COR; R is Hydrogen or lower alkyl; R is Hydrogen or a residue R,And R IS - (CH2) Mr, or R and R, together with the atom of Heterocyclic n associated with them would be a Waste; R is phenyl, phenyl substituted cycloalkyl, heterocyclyl,Lower alkyl, cyano Lower alkyl, Hydroxy alkyl di alkylamino Lower Lower Lower alkyl, carboxy alkyl alkyl alkoxycarbonyl Lower Lower LowerAlkoxycarbonylamino Lower alkyl phenyl - or less - than - alkoxycarbonyl; R is Hydrogen or lower alkyl, Hydroxy alkyl; R is Hydrogen or lower z means; HydroxyAmino - or - or residue, OC (OC (o) NHR, - or, or - NHC (o) NHR - NHC (or means) or heterocyclyl phenyl; R,Lower alkyl or substituted phenyl; and each independently means X is Oxygen or sulfur, nitrogen or CH; M is 0, 1 or 2, and N means 0,1 or 2; usable pharmaceutically and salts thereof are inhibitors of Endothelin Receptor.Therefore, can be used for the treatment of disorders which are associated with the activities of Endothelin, especially Circulatory Disorders such as hypertension, ischemia,Vasospasms and angina.