SUBTITUTED DIARYL-DICARBOXYLIC-DI-GUANIDINES, PROCESS FOR PRODUCING THEM, THEIR USE FOR PREPARING PHARMACEUTICALS, AND DIAGNOSTICS AND PHARMACEUTCAL COMPOSITIONS CONTAINING THEM

摘要

Diaryl dicarboxylic acid diguanidines of formula (I) and their salts are new. One of R1-R5 and one of R6-R10 = CON=C(NH2)2; of the others, R1, R5, R6, R10 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CF3; R32-R34 = H or 1-4C alkyl; R2, R4, R7, R9 = H, F, Cl, Br, I, OH, CN, CF3, CON=C(NH2)2, 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, pyrrol-(1, 2 or 3)-yl (optionally mono- to tetra-substituted by F, Cl, Br, I, CN, 2-8C alkanoyl, 2-8C alkoxycarbonyl, formyl, carboxy, CF3, methyl or methoxy), SO2R22, CONR23R24, COR28, SO2N(R29)R30, OR35 or N(R35)R36; m = 0-2; R14 = 3-8C cycloalkyl or phenyl (optionally mono- - tri-substituted with F, Cl, CF3, methyl, methoxy or N(R15)R16); R15, R16, R23, R24, R29, R30 = H or CH3; R22, R28 = methyl or CF3; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene (optionally with one group substituted by O, S, NH, NCH3 or N-benzyl); R3 = H, SR25, OR25, N(R25)R26, C(R25)(R26)R27; R25 = H, 1-8C alkyl, phenyl (optionally mono- to tri-substituted with F, Cl, CF3, CH3, methoxy, hydroxy, amino, methylamino or dimethylamino), or 1-9C heteroaryl (optionally mono- to tri-substituted by F, Cl, CF3, CH3, OMe, OH, NH2, NHCH3, N(CH3)2); R26, R27 = as R25, or H or 1-8C alkyl; A = bond, N(R11)CO, N(R12)CON(R13), N(R17)CON(R18)SO2, N(R19)SO2, SO2, SO2N(R19)CO, OCON(R19)SO2 or C(R20)=C(R21); and R11 - R21 = H or 1-8C alkyl.