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Anvendelse av tiazoliumforbindelser til forhindring og reversering av dannelse av höyt utviklede glykosyleringssluttprodukter
Anvendelse av tiazoliumforbindelser til forhindring og reversering av dannelse av höyt utviklede glykosyleringssluttprodukter
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机译:使用噻唑鎓化合物预防和逆转高度发达的糖基化终产物的形成
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摘要
The present invention relates to methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
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