ACYLATED N-TERMINAL TETRA- AND PENTAPEPTIDES HAVING AN AMINO ACID RESIDUE CONTAINING AN ACYLATED METHYL GROUP OPTIONALLY SUBSTITUTED AT THE C-TERMINAL BY 5-1H-TETRAZOLYL; USE IN TREATMENT OF HERPES VIRUS INFECTIONS

摘要

Disclosed herein are tetrapeptide derivatives of theformula X-NH-CHR1-C(W1)-NR2-CH[CH2C(O)-Y]-C(W2)-NH-CH-[CR3(R4)-COOH]-C(W3)-NH-CHR3-Z wherein X is a terminalgroup, for example, alkanoyl or phenylalkanoyl radicals, R1 and R5are selected from amino acid or derived amino acid residues, R2 ishydrogen, alkyl or phenylalkyl, R3 and R4 are hydrogen or loweralkyl, W1, W2 and W3 are oxo or thioxo, Y is, for example, analkoxy or a monosubstituted or disubstituted amino, and Z is aterminal group, for example, COOH or CH2OH. The derivativesare useful for treating herpes infections.