ACYLATED N-TERMINAL PENTAPEPTIDES HAVING AN ESTERIFIED OR AMIDIFIED ASPARTIC ACID RESIDUE AND OPTIONALLY SUBSTITUTED AT THE C-TERMINAL BY 5-1H-TETRAZOLYL; USE IN TREATMENT OF HERPES VIRUS INFECTIONS

摘要

Disclosed herein are pentapeptide derivatives of the formula X-NR1-CH(R2)-C(W1)-NH-CR3(R4)-C(W2)-NR5-CH[CH2C(O)-Y]C(W 3)-NH-CR 6- [C R7 (R 8) -C OO H] -C(W4)-NH-CR9(R10)-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 is hydrogen, alkyl or phenylalkyl, R2, R4 and R10 are selected from amino acid or derived amino acid residues, R3, R5, R6, R7, R8 and R9 are hydrogen or alkyl or R7 and R8 are joined to form a cycloalkyl, W1, W2, W3 and W4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections.