ALLERGENIC CRY J II PROTEINS AND CODING SEQUENCES FROM JAPANESE CEDAR POLLEN, THEIR PRODUCTION AND THERAPEUTIC USE

摘要

The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j II and fragments thereof. The present invention also provides purified Cry j II and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j II or at least one fragment thereof and fragments of Cry j prepared synthetically. Cry j II and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis.