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ENTERIC COATED TABLET: ACTIVE CORE, ERODIBLE POLYMER LAYER CONTAINING CELLULOSE ETHER DERIVATIVE, AND ENTERIC OUTER COATING
ENTERIC COATED TABLET: ACTIVE CORE, ERODIBLE POLYMER LAYER CONTAINING CELLULOSE ETHER DERIVATIVE, AND ENTERIC OUTER COATING
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机译:肠溶片:活性核心,含纤维素醚衍生物的易腐蚀聚合物层和肠溶外层
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摘要
A novel delivery system for targeting drugs to the colon is comprised of three parts: (1) an enteric coating to prevent penetration of gastric fluid into the delivery system, thereby preventing any drug release in the stomach; (2) an erodible polymer layer which is exposed and gradually erodes during transit through the upper intestinal tract, and (3) a core, which is a conventional tablet or beadlet containing an active ingredient(s), which readily disintegrates and subsequently releases the drug to the target site, the colon, after erosion of the erodible polymer layer.
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