ANTIHELMINTIC AVERMECTINE DERIVATIVES AND AN AGENT CONTAINING THESE DERIVATIVES, FOR PARASITIC INFECTIONS TREATMENT

摘要

The compounds represented by a general formula (I), where a discontinuous line means a double bond actually and R1 is a hydrogen atom or the OH group and a double bond is not present, in the case a double bond is present, the substituent R1 is absent. R2 is alpha-branched C3-8 alkyl, alpha-branched C3-8 alkenyl, alpha-branched C3-8 alkoxyalkyl or alkoxythioalkyl group, alpha-branched C4-8 alkinyl group, C5-8 cycloalkyl-alpha- -branched C2-5 cycloalkyl group, C3-8 cycloalkyl, C5-8 cycloalkenyl group, heterocycle containing 3 up 6 ring elements, with O or S, total saturated or partial unsaturated, while all of the groups can be substituted by methyl, C1-4 alkyl groups or by halogen atoms. R3 is hydrogen or CH2, R4 is hydrogen or 4'-(alpha-L-oleandrozyl)-alpha-oleandrozyloxy group, explained in this patent description, in more details. Antiparasitic agent containing compounds with a general formula (I) is described in this patent too.