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process for the preparation of particles processed dry processed particles to dry so obtained and pharmaceutical compositions containing the particles
process for the preparation of particles processed dry processed particles to dry so obtained and pharmaceutical compositions containing the particles
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机译:制备颗粒的方法,将加工过的干燥的颗粒干燥以得到如此干燥的方法以及包含该颗粒的药物组合物
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摘要
A method of making microballs is disclosed. An active ingredient, a biocompatible polymer and a supporting phase, such as silicone oil, are stirred at a temperature above the Tg of the polymer and below the temperature at which any of the ingredients vaporizes or degrades. Stirring is continued until microballs of the desired diameter are formed, whereafter the mixture is cooled and the microballs are separated from the supporting phase. The microballs are substantially spherical, substantially smooth on their external surface and have substantially no active ingredient on their external surface.
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