HISTAMINE H3 RECEPTOR AGONISTS FOR THERAPEUTIC USE, PHARMACEUTICAL PREPARATIONS THAT WORK ON H3 RECEPTORS AGONISTIC AND THE METHOD OF THEIR REPRESENTATION

摘要

PCT No. PCT/FR91/00384 Sec. 371 Date Feb. 6, 1992 Sec. 102(e) Date Feb. 6, 1992 PCT Filed May 10, 1991 PCT Pub. No. WO91/17146 PCT Pub. Date Nov. 14, 1991.Agonist compounds of the histamine H3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process are disclosed. The compounds are derived from an amine R-NH2 having a high affinity for the histamine H3 receptor and to the primary amine function of which a group which gives rise to a bond that is capable of being slowly hydrolyzed in a neutral medium is attached. The pharmaceutical compositions contain these compounds and a pharmaceutically acceptable vehicle or excipient. These compounds are used for producing a medicinal product which inhibits the synthesis and the release of histamine, in particular, possessing sedative, sleep-regulating, anticonvulsant, antidepressant, anti-allergic, anti-inflammatory, antisecretory or anti-ulcerous effects.