Polypeptides and proteins having enhanced affinity variants matrices of immobilized metal affinity.

摘要

Proteins and polypeptides variants with improved affinity, THAT IS, THE GREATER FORCE cohesive FOR RESINS METAL Immobilized AFFINITY WITH A aspartic acid residue or histidine IN ONE OR MORE POSITIONS IN A NATURAL PROTEIN are occupied by other amino acid residues, SO THE PROTEIN VARIANT HAS A METALLIC amino acid sequence. SPECIFIC SEQUENCE DEPENDS ON SECONDARY STRUCTURE ASSOCIATED WITH PORTION INCLUDING protein or polypeptide that sequence.