1,4,5-TRIPHENYLPIRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS.

摘要

A CLASS OF 1,4,5-TRIPHENYLPIRAZOLES IS DESCRIBED FOR THE TREATMENT OF INFLAMMATION, INCLUDING THE TREATMENT OF PAIN OR DISORDERS SUCH AS ARTHRITIS. COMPOUNDS OF PARTICULAR INTEREST OF FORMULA (II), WHERE R {SUP, 1} IS CHOSEN FROM THE HYDRID, HALO, ALKYL, ALKYLSUFINYL, ALKYL SULPHYLLYLINOZYL, N-MONOALKYLAMYL, Amino , HALOALKYL, HYDROXY AND ALCOXY; WHERE R {SUP, 2} IS CHOSEN FROM HIDRIDO, ALQUILO, CIANO AND HALOALQUILO, WHERE R {SUP, 3} IS CHOSEN FROM GRUPO HIDRIDO, HALO, ALQUILO, ALQUILSULFINILO, ALQUILSULFINILO -MONOALKYLAMINO, N, NDIALQUILAMINO, ACILAMINO, ACILAQUILAMINO, HALOALQUILO, HIDROXI AND ALCOXI; AND WHERE R {SUP, 4} IS ALKYL OR AMINO; OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS.