STAPHYLOCOCCUS AUREUS COENZYME A DISULFIDE REDUCTASE, AND INHIBITORS THEREOF USEFUL AS ANTIMICROBIAL AGENTS

摘要

An isolated and purified Staphylococcus aureus Coenzyme A disulfide reductase(CoADR) is provided. Oligonucleotides encoding the CoADR, vectors and hostcells containing such oligonucleotides are also provided. In addition,antibodies reactive with the CoADR are provided, as are methods of isolatingthe CoADR, producing recombinant CoADR, using CoADR for screening compoundsfor CoADR-modulating activity, and detecting S. aureus in a test sample.