Staphylococcus aureus coenzyme A disulfide reductase and its inhibitors useful as antimicrobial agents

摘要

An isolated and purified Staphylococcus aureus Coenzyme A disulfide reductase (CoADR) is provided. Oligonucleotides encoding the CoADR, vectors and host cells containing such oligonucleotides are also provided. In addition, antibodies reactive with the CoADR are provided, as are methods of isolating the CoADR, producing recombinant CoADR, using CoADR for screening compounds for CoADR-modulating activity, and detecting S. aureus in a test sample.