IMMORTALIZED HEMATOPOIETIC CELL LINES, CELL SYSTEM THEREOF WITH STROMAL CELLS, IN VITRO, EX VIVO AND IN VIVO USES, AND IN VITRO GENERATION OF DENDRITIC CELLS AND MACROPHAGES

摘要

Extented life hematopoietic cell lines include stromal cell lines useful forthe in vitro maintenance of undifferentiated pluripotent hematopoietic stemcells. Undifferentiated and differentiated immortalized stem cells aresuitable for bone marrow transplantation, gene therapy and cell therapyapplications, and as an in vitro model system for drug discovery andtoxicological testing.