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Methods and compositions for treating hypertension, angina, and other disorders using optically pure S(-) felodipine
Methods and compositions for treating hypertension, angina, and other disorders using optically pure S(-) felodipine
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机译:使用光学纯的S(-)非洛地平治疗高血压,心绞痛和其他疾病的方法和组合物
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摘要
Methods and compositions are disclosed utilizing the optically pure S(-) isomer of felodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of felodipine. The S(-) isomer of felodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of S(-) felodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the administration of the racemic mixture of felodipine.
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