Newer Therapies For Treating Stable Angina and Refractory Angina: Update 2011

摘要

Conventional antianginal drugs (beta-blockers, nitrates and calcium channel blo-ckers) are widely used either as monotherapy or as combination therapy, but many patients remain symptomatic despite treatment with these agents and or following revascularization procedures.Newer therapies are therefore a welcome addition to treat such patients. Rano-lazine, a late sodium channel blocker, is hemodynamically neutral and is equally effective to monotherapy with atenolol and reduces angina frequency when added to a beta-blocker, or amlodipine and a long acting nitrate. Ivabradine, blocks If current in the sinus node and reduces heart rate at rest and during exercise but not the blood pressure and is as effective as atenolol and further increases exercise duration when added to atenolol.