Analogs of botulinum toxin and pharmaceutical compositions o f botulinum toxin

摘要

Novel analogs of botulinum toxin have amino acid residues which are more resistant to degradation in neuromuscular tissue than the amino acid residues in the corresponding natural toxin. Pharmaceutical compositions of botulinum toxin which contain chelating agents for metallic ions and have longer half-lives in neuromuscular tissue than currently available preparations also are disclosed.