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Method of treating cd4+ t cell lymphopenia in immuno-compromised patients
Method of treating cd4+ t cell lymphopenia in immuno-compromised patients
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机译:治疗免疫功能低下患者的cd4 + T细胞淋巴细胞减少的方法
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摘要
The present invention is directed to methods of treating CD4+ T cell lymphopenia in HIV-infected patients. The methods include administering an effective amount of adenosine deaminase or related enzymatic material to a patient in need thereof. In preferred aspects of the invention, the method is employed in conjunction with HIV-infected patients having CD4+ T cell levels of less than about 200/ mu l. Effective amounts of the enzyme range from about 5 to about 50 IU/kg/week. In one particularly preferred aspect of the invention, the adenosine deaminase is conjugated to one or more strands of polyethylene glycol to prolonged activity in vivo.
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机译:本发明涉及治疗HIV感染患者中CD4 + T细胞淋巴细胞减少的方法。该方法包括向有此需要的患者施用有效量的腺苷脱氨酶或相关的酶材料。在本发明的优选方面,该方法与CD4 + T细胞水平小于约200 /μl的HIV感染患者一起使用。酶的有效量为约5至约50IU / kg /周。在本发明的一个特别优选的方面,将腺苷脱氨酶缀合至聚乙二醇的一条或多条链以延长体内活性。
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