Sequence and expression of sox-18

摘要

A gene designated "Sox-18" encodes a transcription factor. A subsequence of the Sox-18 nucleotide sequence has been identified that encodes an activation domain of the Sox-18 transcription factor. Polypeptides comprising all or a part of the Sox-18 expression product can be used to regulate myogenesis, proliferation of skeletal and cardiac muscle, and differentiation of smooth muscle, for example, in the context of treating atherosclerosis, restenosis and pulmonary disease.