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Inhibition of the formation or activity of human leukocyte 12-lipoxygenase pathway
Inhibition of the formation or activity of human leukocyte 12-lipoxygenase pathway
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机译:抑制人白细胞12-脂氧合酶途径的形成或活性
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摘要
The discovery of a new form of 12-lipoxygenase RNA and protein in human adrenal, mononuclear, vascular smooth muscle and endothelial cells is disclosed. Activation of this 12-LO pathway mediates angiotensin II and glucose induced vascular and renal actions. A rationale for the development of pharmaceutical or molecular methods to inhibit this newly discovered lipoxygenase pathway is described.
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