COVALENTLY IMMOBILIZED PHOSPHOLIPID BILAYERS ON SOLID SURFACES

摘要

A solid coated device having covalently attached a coating which comprises a first layer containing first functional groups, to which first layer functional groups is covalently attached a second, linking layer carrying second functional groups, to which second, linking layer is covalently attached a third, proximal phospholipid layer, which third, proximal phospholipid layer, to which third, proximal phospholipid layer is not-covalently attached a fourth, distal lipid layer, so that the proximal and the distal lipid layers together form a bilayer, which lipid bilayer, into which lipid bilayer are optionally inserted receptor molecules, method of the preparation thereof, and uses therof as biosensors or implantation devices.