A process of inhibiting the renin angiotensinogen angiotensin mechanism and treating hypertension administers a blood pressure lowering amount of a protease inhibitor peptide obtained by the cleavage of pepsinogen to a mammal. Hypertension is also treated by administering a blood pressure lowering amount of a stomach mucosa extract from animal origin. The extract is obtained under mild conditions in an extracting solvent containing an acidifying agent.
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