ANTIBIOTICS TKR 400-A AND TKR 400-B AND PROCESSES FOR PRODUCING THESE

摘要

Novel antibiotics useful as a remedy for fungal infections; and a process for producing antibiotic TKR 400-A having the following physicochemical properties or pharmacologically acceptable salts thereof: (1) it gives a mass spectrum having a peak of m/z 1,273 [M+H]+ according to FAB-MS; (2) it gives in methanol an ultraviolet absorption spectrum having major peaks at wavelengths (nm) of 250 sh and 294, whose values of E1%1cm are 96 and 20, respectively; (3) it gives an infrared absorption spectrum by the KBr method which has major peaks at wavenumbers of 3,450, 2,970, 1,680, 1,640, 1,530, 1,410, 1,220 and 1,150 cm-1; (4) threonine, alanine, valine, and isoleucine are detected in the analysis for amino acids by the ninhydrin reaction; and (5) it is soluble in methanol but sparingly soluble in chloroform, water, and hexane.