VACCINE PREPARED USING HUMAN-ORIGIN HANTAAN VIRUS NUCLEOCAPSID PROTEIN EXPRESSED FROM ESCHERICHIA COLI

摘要

A nucleocapsid protein gene obtained by screening human-origin Hantaan virus strains and sequenced; an expression plasmid containing the above gene as a foreign gene; transgenic Escherichia coli prepared by transforming with the above plasmid; a nucleocapsid protein obtained by expressing a protein by culturing the above transformant and purifying the obtained protein; and a vaccine containing the above protein as the active ingredient for preventing hemorrhagic fever with renal syndrome.