NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS

摘要

A non-human mammal genetically modified without affecting its genome and having any two of the following pathological signs: (a) a blood-brain barrier that is open or permeable to water-soluble blood molecules non-specific for the cerebral parenchyma, (b) an astrocyte disorder revealed particularly by physical network disorganisation, the disappearance of perivascular feet around the capillaries, and gliosis, (c) microglial cell activation, (d) demyelinisation plates, particularly in the brain stem and/or the cerebral white matter, and (e) central nervous system glial and endothelial cell lesions, as well as the uses of said animal, are disclosed.