NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS

摘要

(57) Abstract Without producing effect to the genome, being fault - human Mammalia qualification, (a) in brain substantial system the blood brain barrier which is opening or permeability vis-a-vis the non unique water soluble blood numerator; The star condition cell abnormality which appears (b) with confusion of especially physiology network, disappearance, and gurioshisu of the star condition foot around the capillarity tube; (C) micro gloea cell activation; (D) the especially brain stem and/or deviation from medulla puraku which exists in the brain white matter; And (e) the application of Mammalia and the aforementioned animal which inside the central nervous system gloea cell and endotherium fault at least possess two signs is disclosed.